The C-terminal Region of the Exosome-associated Protein Rrp47 Is Specifically Required for Box C/d Snorna 3' Maturation

1 THE C-TERMINAL REGION OF THE EXOSOME-ASSOCIATED PROTEIN RRP47 IS SPECIFICALLY REQUIRED FOR BOX C/D SNORNA 3' MATURATION Joe L. Costello, Jonathan A. Stead, Monika Feigenbutz, Rebecca M. Jones and Phil Mitchell From the Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK Running head: Rrp47 interacts with snoRNP proteins Present address: The University of Manchester, Faculty of Life Sciences, Manchester M13 9PT, UK Present address: The Institute of Cancer Studies, The University of Sheffield, Sheffield S10 5GB, UK Present address: The School of Cancer Studies, The University of Birmingham, Birmingham B15 2TT, UK Address correspondence to: Phil Mitchell, Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK; E-mail: [email protected]